Studies on Azine Compounds. I

Cv. the Azine and Azonium Compounds of the Proteolytic Enzymes

THE immense importance of the establishment of the chemical nature of the proteolytic enzymes has led to many endeavours to purify them. From the earliest attempts of Schwann [1836] to the present day all these have met with obvious failure. In 1905 it was observed by T. Brailsford Robertson [1907] that if one drop of saturated safranine (Griibler) is added to a solution of trypsin (Griibler) a...

The reaction of azine compounds with proteolytic enzymes.

Studies on the delayed neurotoxicity of organophosphorus compounds- (I).

Delayed neurotoxicity experiments of an organophosphorus compound, TOCP, on hens and quails were carried out. The animals were orally exposed with TOCP in dose of 400 mg/kg, and maintained for 25 and 50 days under observation, respectively. They were sacrificed and dissected at different periods after the exposure, and the histopathological examinations were made on those animals. During the pe...

4-(Diethyl­amino)­salicyl­aldehyde azine

The title compound, C(22)H(30)N(4)O(2), has a crystallographic inversion center located at the mid-point of the N-N single bond. Apart from the four ethyl C atoms, the non-H atoms are nearly coplanar with a mean deviation of 0.0596 (2) Å. An intra-molecular O-H⋯N hydrogen bond occurs. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into layers parallel to (100).

2,4-Dimethoxy­benzaldehyde azine

The title mol-ecule, C(18)H(20)N(2)O(4), is located on a crystallographic centre of symmetry. The meth-oxy groups are coplanar with the benzene ring [interplanar angles of 14.4 (2) and 3.1 (3)°], indicating a conjugation effect.